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Role of Aromatic Side Chains in Amyloid β-Protein Aggregation

[Image: see text] Aggregation of the amyloid β-protein (Aβ) is believed to be involved in Alzheimer’s disease pathogenesis. Here we have investigated the importance of the aromatic rings at positions 19 and 20 for the aggregation rate and mechanism by substituting phenylalanine with leucine. Aggrega...

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Main Authors: Cukalevski, Risto, Boland, Barry, Frohm, Birgitta, Thulin, Eva, Walsh, Dominic, Linse, Sara
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2012
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526965/
https://ncbi.nlm.nih.gov/pubmed/23259036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn300073s
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