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Role of Aromatic Side Chains in Amyloid β-Protein Aggregation
[Image: see text] Aggregation of the amyloid β-protein (Aβ) is believed to be involved in Alzheimer’s disease pathogenesis. Here we have investigated the importance of the aromatic rings at positions 19 and 20 for the aggregation rate and mechanism by substituting phenylalanine with leucine. Aggrega...
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| Autors principals: | , , , , , |
|---|---|
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Chemical
Society
2012
|
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3526965/ https://ncbi.nlm.nih.gov/pubmed/23259036 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn300073s |
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