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Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors
Understanding the mechanism of action of compounds capable of inhibiting amyloid-fibril formation is critical to the development of potential therapeutics against protein-misfolding diseases. A fundamental challenge for progress is the range of possible target species and the disparate timescales in...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7533883/ https://ncbi.nlm.nih.gov/pubmed/32929030 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2006684117 |
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