A rationally designed bicyclic peptide remodels Aβ42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer’s disease

Bicyclic peptides have great therapeutic potential since they can bridge the gap between small molecules and antibodies by combining a low molecular weight of about 2 kDa with an antibody-like binding specificity. Here we apply a recently developed in silico rational design strategy to produce a bic...

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Publicado no:Sci Rep
Main Authors: Ikenoue, Tatsuya, Aprile, Francesco A., Sormanni, Pietro, Ruggeri, Francesco S., Perni, Michele, Heller, Gabriella T., Haas, Christian P., Middel, Christoph, Limbocker, Ryan, Mannini, Benedetta, Michaels, Thomas C. T., Knowles, Tuomas P. J., Dobson, Christopher M., Vendruscolo, Michele
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7498612/
https://ncbi.nlm.nih.gov/pubmed/32943652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-69626-3
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