Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease

Disordered proteins are challenging therapeutic targets, and no drug is currently in clinical use that modifies the properties of their monomeric states. Here, we identify a small molecule (10074-G5) capable of binding and sequestering the intrinsically disordered amyloid-β (Aβ) peptide in its monom...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Heller, Gabriella T., Aprile, Francesco A., Michaels, Thomas C. T., Limbocker, Ryan, Perni, Michele, Ruggeri, Francesco Simone, Mannini, Benedetta, Löhr, Thomas, Bonomi, Massimiliano, Camilloni, Carlo, De Simone, Alfonso, Felli, Isabella C., Pierattelli, Roberta, Knowles, Tuomas P. J., Dobson, Christopher M., Vendruscolo, Michele
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7673680/
https://ncbi.nlm.nih.gov/pubmed/33148639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb5924
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