An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease

The conversion of the β-amyloid (Aβ) peptide into pathogenic aggregates is linked to the onset and progression of Alzheimer’s disease. Although this observation has prompted an extensive search for therapeutic agents to modulate the concentration of Aβ or inhibit its aggregation, all clinical trials...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Habchi, Johnny, Arosio, Paolo, Perni, Michele, Costa, Ana Rita, Yagi-Utsumi, Maho, Joshi, Priyanka, Chia, Sean, Cohen, Samuel I. A., Müller, Martin B. D., Linse, Sara, Nollen, Ellen A. A., Dobson, Christopher M., Knowles, Tuomas P. J., Vendruscolo, Michele
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4758743/
https://ncbi.nlm.nih.gov/pubmed/26933687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1501244
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