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Infrared nanospectroscopy reveals the molecular interaction fingerprint of an aggregation inhibitor with single Aβ42 oligomers

Significant efforts have been devoted in the last twenty years to developing compounds that can interfere with the aggregation pathways of proteins related to misfolding disorders, including Alzheimer’s and Parkinson’s diseases. However, no disease-modifying drug has become available for clinical us...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Ruggeri, Francesco Simone, Habchi, Johnny, Chia, Sean, Horne, Robert I., Vendruscolo, Michele, Knowles, Tuomas P. J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2021
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7846799/
https://ncbi.nlm.nih.gov/pubmed/33514697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20782-0
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