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Infrared nanospectroscopy reveals the molecular interaction fingerprint of an aggregation inhibitor with single Aβ42 oligomers

Significant efforts have been devoted in the last twenty years to developing compounds that can interfere with the aggregation pathways of proteins related to misfolding disorders, including Alzheimer’s and Parkinson’s diseases. However, no disease-modifying drug has become available for clinical us...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Ruggeri, Francesco Simone, Habchi, Johnny, Chia, Sean, Horne, Robert I., Vendruscolo, Michele, Knowles, Tuomas P. J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2021
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7846799/
https://ncbi.nlm.nih.gov/pubmed/33514697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20782-0
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