Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers

[Image: see text] Alzheimer’s disease is associated with the deposition of the amyloid-β peptide (Aβ) into extracellular senile plaques in the brain. In vitro and in vivo observations have indicated that transthyretin (TTR) acts as an Aβ scavenger in the brain, but the mechanism has not been fully r...

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Detalhes bibliográficos
Publicado no:Biomacromolecules
Main Authors: Ghadami, Seyyed Abolghasem, Chia, Sean, Ruggeri, Francesco Simone, Meisl, Georg, Bemporad, Francesco, Habchi, Johnny, Cascella, Roberta, Dobson, Christopher M., Vendruscolo, Michele, Knowles, Tuomas P. J., Chiti, Fabrizio
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7997117/
https://ncbi.nlm.nih.gov/pubmed/32011129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biomac.9b01475
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