Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers

[Image: see text] Alzheimer’s disease is associated with the deposition of the amyloid-β peptide (Aβ) into extracellular senile plaques in the brain. In vitro and in vivo observations have indicated that transthyretin (TTR) acts as an Aβ scavenger in the brain, but the mechanism has not been fully r...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Biomacromolecules
Autores principales: Ghadami, Seyyed Abolghasem, Chia, Sean, Ruggeri, Francesco Simone, Meisl, Georg, Bemporad, Francesco, Habchi, Johnny, Cascella, Roberta, Dobson, Christopher M., Vendruscolo, Michele, Knowles, Tuomas P. J., Chiti, Fabrizio
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2020
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7997117/
https://ncbi.nlm.nih.gov/pubmed/32011129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biomac.9b01475
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares