Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

The onset and progression of numerous protein misfolding diseases are associated with the presence of oligomers formed during the aberrant aggregation of several different proteins, including amyloid-β (Aβ) in Alzheimer’s disease and α-synuclein (αS) in Parkinson’s disease. These small, soluble aggr...

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Publicado no:Commun Biol
Main Authors: Limbocker, Ryan, Mannini, Benedetta, Ruggeri, Francesco S., Cascella, Roberta, Xu, Catherine K., Perni, Michele, Chia, Sean, Chen, Serene W., Habchi, Johnny, Bigi, Alessandra, Kreiser, Ryan P., Wright, Aidan K., Albright, J. Alex, Kartanas, Tadas, Kumita, Janet R., Cremades, Nunilo, Zasloff, Michael, Cecchi, Cristina, Knowles, Tuomas P. J., Chiti, Fabrizio, Vendruscolo, Michele, Dobson, Christopher M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7426408/
https://ncbi.nlm.nih.gov/pubmed/32792544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01140-8
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