Trodusquemine enhances Aβ(42) aggregation but suppresses its toxicity by displacing oligomers from cell membranes

Transient oligomeric species formed during the aggregation process of the 42-residue form of the amyloid-β peptide (Aβ(42)) are key pathogenic agents in Alzheimer’s disease (AD). To investigate the relationship between Aβ(42) aggregation and its cytotoxicity and the influence of a potential drug on...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nat Commun
Hauptverfasser: Limbocker, Ryan, Chia, Sean, Ruggeri, Francesco S., Perni, Michele, Cascella, Roberta, Heller, Gabriella T., Meisl, Georg, Mannini, Benedetta, Habchi, Johnny, Michaels, Thomas C. T., Challa, Pavan K., Ahn, Minkoo, Casford, Samuel T., Fernando, Nilumi, Xu, Catherine K., Kloss, Nina D., Cohen, Samuel I. A., Kumita, Janet R., Cecchi, Cristina, Zasloff, Michael, Linse, Sara, Knowles, Tuomas P. J., Chiti, Fabrizio, Vendruscolo, Michele, Dobson, Christopher M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333784/
https://ncbi.nlm.nih.gov/pubmed/30644384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07699-5
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge