Exogenous misfolded protein oligomers can cross the intestinal barrier and cause a disease phenotype in C. elegans

Misfolded protein oligomers are increasingly recognized as highly cytotoxic agents in a wide range of human disorders associated with protein aggregation. In this study, we assessed the possible uptake and resulting toxic effects of model protein oligomers administered to C. elegans through the cult...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Perni, Michele, Mannini, Benedetta, Xu, Catherine K., Kumita, Janet R., Dobson, Christopher M., Chiti, Fabrizio, Vendruscolo, Michele
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8277765/
https://ncbi.nlm.nih.gov/pubmed/34257326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-93527-8
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