Current trends and challenges in the downstream purification of bispecific antibodies

od Chen, Serene W, Zhang, Wei
izdano v Antib Ther (2021)

Investigation of the effect of salt additives in Protein L affinity chromatography for the purification of tandem single-chain variable fragment bispecific antibodies

od Chen, Serene W., Tan, Darryl, Yang, Yuan Sheng, Zhang, Wei
izdano v MAbs (2020)

Exploring the Release of Toxic Oligomers from α-Synuclein Fibrils with Antibodies and STED Microscopy

od Bigi, Alessandra, Ermini, Emilio, Chen, Serene W., Cascella, Roberta, Cecchi, Cristina
izdano v Life (Basel) (2021)

Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies

od Cascella, Roberta, Perni, Michele, Chen, Serene W., Fusco, Giuliana, Cecchi, Cristina, Vendruscolo, Michele, Chiti, Fabrizio, Dobson, Christopher M., De Simone, Alfonso
izdano v ACS Chem Biol (2019)

The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells

od Cascella, Roberta, Chen, Serene W., Bigi, Alessandra, Camino, José D., Xu, Catherine K., Dobson, Christopher M., Chiti, Fabrizio, Cremades, Nunilo, Cecchi, Cristina
izdano v Nat Commun (2021)

Amyloid-β and α-Synuclein Decrease the Level of Metal-Catalyzed Reactive Oxygen Species by Radical Scavenging and Redox Silencing

od Pedersen, Jeppe T., Chen, Serene W., Borg, Christian B., Ness, Samuel, Bahl, Justyna M., Heegaard, Niels H. H., Dobson, Christopher M., Hemmingsen, Lars, Cremades, Nunilo, Teilum, Kaare
izdano v J Am Chem Soc (2016)

The extent of protein hydration dictates the preference for heterogeneous or homogeneous nucleation generating either parallel or antiparallel β-sheet α-synuclein aggregates

od Camino, José D., Gracia, Pablo, Chen, Serene W., Sot, Jesús, de la Arada, Igor, Sebastián, Víctor, Arrondo, José L. R., Goñi, Félix M., Dobson, Christopher M., Cremades, Nunilo
izdano v Chem Sci (2020)

Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids

od Horrocks, Mathew H., Lee, Steven F., Gandhi, Sonia, Magdalinou, Nadia K., Chen, Serene W., Devine, Michael J., Tosatto, Laura, Kjaergaard, Magnus, Beckwith, Joseph S., Zetterberg, Henrik, Iljina, Marija, Cremades, Nunilo, Dobson, Christopher M., Wood, Nicholas W., Klenerman, David
izdano v ACS Chem Neurosci (2016)

Defining α-synuclein species responsible for Parkinson's disease phenotypes in mice

od Froula, Jessica M., Castellana-Cruz, Marta, Anabtawi, Nadia M., Camino, José D., Chen, Serene W., Thrasher, Drake R., Freire, Jennifer, Yazdi, Allen A., Fleming, Sheila, Dobson, Christopher M., Kumita, Janet R., Cremades, Nunilo, Volpicelli-Daley, Laura A.
izdano v J Biol Chem (2019)

Correction: Defining α-synuclein species responsible for Parkinson's disease phenotypes in mice.

od Froula, Jessica M., Castellana-Cruz, Marta, Anabtawi, Nadia M., Camino, José D., Chen, Serene W., Thrasher, Drake R., Freire, Jennifer, Yazdi, Allen A., Fleming, Sheila, Dobson, Christopher M., Kumita, Janet R., Cremades, Nunilo, Volpicelli-Daley, Laura A.
izdano v J Biol Chem (2020)

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation

od Chen, Serene W., Drakulic, Srdja, Deas, Emma, Ouberai, Myriam, Aprile, Francesco A., Arranz, Rocío, Ness, Samuel, Roodveldt, Cintia, Guilliams, Tim, De-Genst, Erwin J., Klenerman, David, Wood, Nicholas W., Knowles, Tuomas P.J., Alfonso, Carlos, Rivas, Germán, Abramov, Andrey Y., Valpuesta, José María, Dobson, Christopher M., Cremades, Nunilo
izdano v Proc Natl Acad Sci U S A (2015)

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

od Limbocker, Ryan, Mannini, Benedetta, Ruggeri, Francesco S., Cascella, Roberta, Xu, Catherine K., Perni, Michele, Chia, Sean, Chen, Serene W., Habchi, Johnny, Bigi, Alessandra, Kreiser, Ryan P., Wright, Aidan K., Albright, J. Alex, Kartanas, Tadas, Kumita, Janet R., Cremades, Nunilo, Zasloff, Michael, Cecchi, Cristina, Knowles, Tuomas P. J., Chiti, Fabrizio, Vendruscolo, Michele, Dobson, Christopher M.
izdano v Commun Biol (2020)

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

od Perni, Michele, Galvagnion, Céline, Maltsev, Alexander, Meisl, Georg, Müller, Martin B. D., Challa, Pavan K., Kirkegaard, Julius B., Flagmeier, Patrick, Cohen, Samuel I. A., Cascella, Roberta, Chen, Serene W., Limbocker, Ryan, Sormanni, Pietro, Heller, Gabriella T., Aprile, Francesco A., Cremades, Nunilo, Cecchi, Cristina, Chiti, Fabrizio, Nollen, Ellen A. A., Knowles, Tuomas P. J., Vendruscolo, Michele, Bax, Adriaan, Zasloff, Michael, Dobson, Christopher M.
izdano v Proc Natl Acad Sci U S A (2017)

Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease

od Perni, Michele, van der Goot, Annemieke, Limbocker, Ryan, van Ham, Tjakko J., Aprile, Francesco A., Xu, Catherine K., Flagmeier, Patrick, Thijssen, Karen, Sormanni, Pietro, Fusco, Giuliana, Chen, Serene W., Challa, Pavan K., Kirkegaard, Julius B., Laine, Romain F., Ma, Kai Yu, Müller, Martin B. D., Sinnige, Tessa, Kumita, Janet R., Cohen, Samuel I. A., Seinstra, Renée, Kaminski Schierle, Gabriele S., Kaminski, Clemens F., Barbut, Denise, De Simone, Alfonso, Knowles, Tuomas P. J., Zasloff, Michael, Nollen, Ellen A. A., Vendruscolo, Michele, Dobson, Christopher M.
izdano v Front Cell Dev Biol (2021)