Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies

[Image: see text] The aggregation of α-synuclein, a protein involved in neurotransmitter release at presynaptic terminals, is associated with a range of highly debilitating neurodegenerative conditions, most notably Parkinson’s disease. Intraneuronal inclusion bodies, primarily composed of α-synucle...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Cascella, Roberta, Perni, Michele, Chen, Serene W., Fusco, Giuliana, Cecchi, Cristina, Vendruscolo, Michele, Chiti, Fabrizio, Dobson, Christopher M., De Simone, Alfonso
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007184/
https://ncbi.nlm.nih.gov/pubmed/31050886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00312
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