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The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State

The aggregation of α-synuclein (αS), a protein abundant at presynaptic terminals, is associated with a range of highly debilitating neurodegenerative conditions, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). Emerging evidence indicates that th...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Runfola, Matteo, De Simone, Alfonso, Vendruscolo, Michele, Dobson, Christopher M., Fusco, Giuliana
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959233/
https://ncbi.nlm.nih.gov/pubmed/31937832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-57023-4
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