Direct Observation of the Three Regions in α-Synuclein that Determine its Membrane-Bound Behaviour

α-synuclein (αS) is a protein involved in neurotransmitter release in presynaptic terminals, and whose aberrant aggregation is associated with Parkinson’s disease. In dopaminergic neurons, αS exists in a tightly regulated equilibrium between water-soluble and membrane-associated forms. Here we used...

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Bibliographic Details
Main Authors: Fusco, Giuliana, De Simone, Alfonso, Tata, Gopinath, Vostrikov, Vitaly, Vendruscolo, Michele, Dobson, Christopher M., Veglia, Gianluigi
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046108/
https://ncbi.nlm.nih.gov/pubmed/24871041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4827
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