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The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition

α-Synuclein (αS) is a presynaptic disordered protein whose aberrant aggregation is associated with Parkinson’s disease. The functional role of αS is still debated, although it has been involved in the regulation of neurotransmitter release via the interaction with synaptic vesicles (SVs). We report...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Man, Wing K., Tahirbegi, Bogachan, Vrettas, Michail D., Preet, Swapan, Ying, Liming, Vendruscolo, Michele, De Simone, Alfonso, Fusco, Giuliana
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7876145/
https://ncbi.nlm.nih.gov/pubmed/33568632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21027-4
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