731. Pharmacokinetics of Gepotidacin (GSK2140944) in Subjects with Hepatic Impairment

Por Hands, Jonathan T, Tao, Yu, Tiffany, Courtney, Perry, Caroline R, Dumont, Etienne, Hossain, Mohammad
Publicado no Open Forum Infect Dis (2019)

Sources and Importance of Mitochondrial NAD

Por Baur, Joseph, Luongo, Timothy, Eller, Jared, Lu, Mu-Jie, Perry, Caroline, Cambronne, Lulu
Publicado no Innov Aging (2020)

Albiglutide Does Not Prolong QTc Interval in Healthy Subjects: A Thorough ECG Study

Por Darpo, Borje, Zhou, Meijian, Matthews, Jessica, Zhi, Hui, Young, Malcolm A., Perry, Caroline, Reinhardt, Rickey R.
Publicado em 2014

Erratum to: Albiglutide Does Not Prolong QTc Interval in Healthy Subjects: A Thorough ECG Study

Por Darpo, Borje, Zhou, Meijian, Matthews, Jessica, Zhi, Hui, Young, Malcolm A., Perry, Caroline, Reinhardt, Rickey R.
Publicado no Diabetes Ther (2014)

Efficacy, Safety, and Tolerability of Gepotidacin (GSK2140944) in the Treatment of Patients with Suspected or Confirmed Gram-Positive Acute Bacterial Skin and Skin Structure Infect...

Por O'Riordan, William, Tiffany, Courtney, Scangarella-Oman, Nicole, Perry, Caroline, Hossain, Mohammad, Ashton, Teri, Dumont, Etienne
Publicado no Antimicrob Agents Chemother (2017)

1482. Microbiological Analysis from a Phase II Study Evaluating Gepotidacin (GSK2140944) in the Treatment of Uncomplicated Urinary Tract Infections

Por Scangarella-Oman, Nicole, Hossain, Mohammad, Tiemeyer Jr., Timothy, Perry, Caroline R, Tiffany, Courtney, Raychaudhuri, Aparna, Dumont, Etienne
Publicado no Open Forum Infect Dis (2019)

1480. Plasma and Urine Pharmacokinetic Analysis of Gepotidacin (GSK2140944) Following BID Oral Dosing in a Phase IIa Study for Treatment of Uncomplicated Urinary Tract Infections

Por Zimmerman, Eric I, Dumont, Etienne, Perry, Caroline R, Tiffany, Courtney, Scangarella-Oman, Nicole, Raychaudhuri, Aparna, Hossain, Mohammad
Publicado no Open Forum Infect Dis (2019)

1479. Clinical Efficacy and Safety Analysis Evaluating Oral Gepotidacin (GSK2140944) from a Phase IIa Study in the Treatment of Uncomplicated Urinary Tract Infections

Por Overcash, J Scott, Dumont, Etienne, Perry, Caroline R, Tiffany, Courtney, Scangarella-Oman, Nicole, Raychaudhuri, Aparna, Hossain, Mohammad
Publicado no Open Forum Infect Dis (2019)

Efficacy and safety of once-weekly GLP-1 receptor agonist albiglutide (HARMONY 2): 52 week primary endpoint results from a randomised, placebo-controlled trial in patients with typ...

Por Nauck, Michael A., Stewart, Murray W., Perkins, Christopher, Jones-Leone, Angela, Yang, Fred, Perry, Caroline, Reinhardt, Rickey R., Rendell, Marc
Publicado no Diabetologia (2015)

1281. Longitudinal and Spatial Variation in the Human Microbiome in a Phase 2a Clinical Study of Gepotidacin in Adult Females with Uncomplicated Urinary Tract Infection

Por Nuzzo, Andrea, Van Horn, Stephanie, Traini, Christopher, Perry, Caroline R, Dumont, Etienne, Scangarella-Oman, Nicole, Gardiner, David, Brown, James R
Publicado no Open Forum Infect Dis (2020)

Phase 2a Pharmacokinetic, Safety, and Exploratory Efficacy Evaluation of Oral Gepotidacin (GSK2140944) in Female Participants with Uncomplicated Urinary Tract Infection (Acute Unco...

Por Overcash, J. Scott, Tiffany, Courtney A., Scangarella-Oman, Nicole E., Perry, Caroline R., Tao, Yu, Hossain, Mohammad, Barth, Aline, Dumont, Etienne F.
Publicado no Antimicrob Agents Chemother (2020)

Tissue metabolic profiling shows that saccharopine accumulates during renal ischemic-reperfusion injury, while kynurenine and itaconate accumulate in renal allograft rejection

Por Beier, Ulf H., Hartung, Erum A., Concors, Seth, Hernandez, Paul T., Wang, Zhonglin, Perry, Caroline, Baur, Joseph A., Denburg, Michelle R., Hancock, Wayne W., Gade, Terence P., Levine, Matthew H.
Publicado no Metabolomics (2020)

Gepotidacin for the Treatment of Uncomplicated Urogenital Gonorrhea: A Phase 2, Randomized, Dose-Ranging, Single-Oral Dose Evaluation

Por Taylor, Stephanie N, Morris, David H, Avery, Ann K, Workowski, Kimberly A, Batteiger, Byron E, Tiffany, Courtney A, Perry, Caroline R, Raychaudhuri, Aparna, Scangarella-Oman, Nicole E, Hossain, Mohammad, Dumont, Etienne F
Publicado no Clin Infect Dis (2018)

Microbiological Analysis from a Phase 2 Randomized Study in Adults Evaluating Single Oral Doses of Gepotidacin in the Treatment of Uncomplicated Urogenital Gonorrhea Caused by Neis...

Por Scangarella-Oman, Nicole E., Hossain, Mohammad, Dixon, Paula B., Ingraham, Karen, Min, Sharon, Tiffany, Courtney A., Perry, Caroline R., Raychaudhuri, Aparna, Dumont, Etienne F., Huang, Jianzhong, Hook, Edward W., Miller, Linda A.
Publicado no Antimicrob Agents Chemother (2018)

In Vitro Activity and Microbiological Efficacy of Gepotidacin from a Phase 2, Randomized, Multicenter, Dose-Ranging Study in Patients with Acute Bacterial Skin and Skin Structure I...

Por Scangarella-Oman, Nicole E., Ingraham, Karen A., Tiffany, Courtney A., Tomsho, Lynn, Van Horn, Stephanie F., Mayhew, David N., Perry, Caroline R., Ashton, Theresa C., Dumont, Etienne F., Huang, Jianzhong, Brown, James R., Miller, Linda A.
Publicado no Antimicrob Agents Chemother (2020)

Polyunsaturated Fatty Acids from Astrocytes Activate PPAR Gamma Signaling in Cancer Cells to Promote Brain Metastasis

Por Zou, Yongkang, Watters, Andrea, Cheng, Nan, Perry, Caroline E, Xu, Ke, Alicea, Gretchen M, Parris, Joshua L.D, Baraban, Ezra, Ray, Pulak, Nayak, Anupma, Xu, Xiaowei, Herlyn, Meenhard, Murphy, Maureen E, Weeraratna, Ashani T, Schug, Zachary T., Chen, Qing
Publicado no Cancer Discov (2019)

Using rapid point-of-care tests to inform antibiotic choice to mitigate drug resistance in gonorrhoea

Por Vegvari, Carolin, Grad, Yonatan H, White, Peter J, Didelot, Xavier, Whittles, Lilith K, Scangarella-Oman, Nicole E, Mitrani-Gold, Fanny S, Dumont, Etienne, Perry, Caroline R, Gilchrist, Kim, Hossain, Mohammad, Mortimer, Tatum D, Anderson, Roy M, Gardiner, David
Publicado no Euro Surveill (2020)

Enzymatic cleavage of uracil-containing single-stranded DNA linkers for the efficient release of affinity-selected circulating tumor cells

Por Nair, Soumya V., Witek, Małgorzata A., Jackson, Joshua M., Lindell, Maria A. M., Hunsucker, Sally A., Sapp, Travis, Perry, Caroline E., Hupert, Mateusz L., Bae-Jump, Victoria, Gehrig, Paola A., Wysham, Weiya Z., Armistead, Paul M., Voorhees, Peter, Soper, Steven A.
Publicado no Chem Commun (Camb) (2015)

SLC25A51 is a mammalian mitochondrial NAD(+) transporter

Por Luongo, Timothy S., Eller, Jared M., Lu, Mu-Jie, Niere, Marc, Raith, Fabio, Perry, Caroline, Bornstein, Marc R., Oliphint, Paul, Wang, Lin, McReynolds, Melanie R., Migaud, Marie E., Rabinowitz, Joshua D., Johnson, F. Brad, Johnsson, Kai, Ziegler, Mathias, Cambronne, Xiaolu A., Baur, Joseph A.
Publicado no Nature (2020)

Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy

Por Kopinski, Piotr K., Janssen, Kevin A., Schaefer, Patrick M., Trefely, Sophie, Perry, Caroline E., Potluri, Prasanth, Tintos-Hernandez, Jesus A., Singh, Larry N., Karch, Kelly R., Campbell, Sydney L., Doan, Mary T., Jiang, Helen, Nissim, Itzhak, Nakamaru-Ogiso, Eiko, Wellen, Kathryn E., Snyder, Nathaniel W., Garcia, Benjamin A., Wallace, Douglas C.
Publicado no Proc Natl Acad Sci U S A (2019)