Phase 2a Pharmacokinetic, Safety, and Exploratory Efficacy Evaluation of Oral Gepotidacin (GSK2140944) in Female Participants with Uncomplicated Urinary Tract Infection (Acute Uncomplicated Cystitis)

Gepotidacin, a triazaacenaphthylene bacterial type II topoisomerase inhibitor, is in development for treatment of uncomplicated urinary tract infection (uUTI). This phase 2a study in female participants with uUTI evaluated the pharmacokinetics (primary objective), safety, and exploratory efficacy of...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Overcash, J. Scott, Tiffany, Courtney A., Scangarella-Oman, Nicole E., Perry, Caroline R., Tao, Yu, Hossain, Mohammad, Barth, Aline, Dumont, Etienne F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318048/
https://ncbi.nlm.nih.gov/pubmed/32284384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00199-20
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