Enzymatic cleavage of uracil-containing single-stranded DNA linkers for the efficient release of affinity-selected circulating tumor cells

We report a novel strategy to enzymatically release affinity-selected cells, such as circulating tumor cells (CTCs), from surfaces with high efficiency (~90%) while maintaining cell viability (>85%). The strategy utilizes single-stranded DNAs that link a capture antibody to the surfaces of a CTC...

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Publicado en:Chem Commun (Camb)
Main Authors: Nair, Soumya V., Witek, Małgorzata A., Jackson, Joshua M., Lindell, Maria A. M., Hunsucker, Sally A., Sapp, Travis, Perry, Caroline E., Hupert, Mateusz L., Bae-Jump, Victoria, Gehrig, Paola A., Wysham, Weiya Z., Armistead, Paul M., Voorhees, Peter, Soper, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552044/
https://ncbi.nlm.nih.gov/pubmed/25616078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4cc09765c
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