1440. The Genetic Basis for a Neisseria gonorrhoeae Clinical Isolate That Contains mtrR(-79) Mutation But Is Highly Susceptible to Antibiotics Effluxed by the Mtr Pump System

door Huang, Jianzhong, Ingraham, Karen
Gepubliceerd in Open Forum Infect Dis (2020)

1438. Dissecting the Multifaceted Nature of Antibiotic Resistance in Clinical Isolates of Neisseria gonorrhoeae by Natural Transformation

door Huang, Jianzhong, Ingraham, Karen, Chan, Pan, Rittenhouse, Steve
Gepubliceerd in Open Forum Infect Dis (2020)

1249. Genetic Evidence That Gepotidacin Shows Well-balanced Dual Targeting against DNA Gyrase And Topoisomerase IV in Neisseria gonorrhoeae

door Chan, Pan, Ingraham, Karen, Min, Sharon, Scangarella-Oman, Nicole, Rittenhouse, Steve, Huang, Jianzhong
Gepubliceerd in Open Forum Infect Dis (2020)

Horizontal transfer of drug-resistant aminoacyl-transfer-RNA synthetases of anthrax and Gram-positive pathogens

door Brown, James R., Gentry, Daniel, Becker, Julie A., Ingraham, Karen, Holmes, David J., Stanhope, Michael J.
Gepubliceerd in 2003

Comparative Genomics of Klebsiella pneumoniae Strains with Different Antibiotic Resistance Profiles

door Kumar, Vinod, Sun, Peng, Vamathevan, Jessica, Li, Yong, Ingraham, Karen, Palmer, Leslie, Huang, Jianzhong, Brown, James R.
Gepubliceerd in 2011

Variable Sensitivity to Bacterial Methionyl-tRNA Synthetase Inhibitors Reveals Subpopulations of Streptococcus pneumoniae with Two Distinct Methionyl-tRNA Synthetase Genes

door Gentry, Daniel R., Ingraham, Karen A., Stanhope, Michael J., Rittenhouse, Stephen, Jarvest, Richard L., O'Hanlon, Peter J., Brown, James R., Holmes, David J.
Gepubliceerd in 2003

Relationship between Gepotidacin Exposure and Prevention of On-Therapy Resistance Amplification in a Neisseria gonorrhoeae Hollow-Fiber In Vitro Infection Model

door VanScoy, Brian D., Scangarella-Oman, Nicole E., Fikes, Steven, Min, Sharon, Huang, Jianzhong, Ingraham, Karen, Bhavnani, Sujata M., Conde, Haley, Ambrose, Paul G.
Gepubliceerd in Antimicrob Agents Chemother (2020)

Identification, Evolution, and Essentiality of the Mevalonate Pathway for Isopentenyl Diphosphate Biosynthesis in Gram-Positive Cocci

door Wilding, E. Imogen, Brown, James R., Bryant, Alexander P., Chalker, Alison F., Holmes, David J., Ingraham, Karen A., Iordanescu, Serban, So, Chi Y., Rosenberg, Martin, Gwynn, Michael N.
Gepubliceerd in 2000

Characterization of a Novel Fucose-Regulated Promoter (P(fcsK)) Suitable for Gene Essentiality and Antibacterial Mode-of-Action Studies in Streptococcus pneumoniae

door Chan, Pan F., O'Dwyer, Karen M., Palmer, Leslie M., Ambrad, Jennifer D., Ingraham, Karen A., So, Chi, Lonetto, Michael A., Biswas, Sanjoy, Rosenberg, Martin, Holmes, David J., Zalacain, Magdalena
Gepubliceerd in 2003

Microbiome Changes in Healthy Volunteers Treated with GSK1322322, a Novel Antibiotic Targeting Bacterial Peptide Deformylase

door Arat, Seda, Spivak, Aaron, Van Horn, Stephanie, Thomas, Elizabeth, Traini, Christopher, Sathe, Ganesh, Livi, George P., Ingraham, Karen, Jones, Lori, Aubart, Kelly, Holmes, David J., Naderer, Odin, Brown, James R.
Gepubliceerd in Antimicrob Agents Chemother (2015)

Frequency of Spontaneous Resistance to Peptide Deformylase Inhibitor GSK1322322 in Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoni...

door Min, Sharon, Ingraham, Karen, Huang, Jianzhong, McCloskey, Lynn, Rilling, Sarah, Windau, Anne, Pizzollo, Jason, Butler, Deborah, Aubart, Kelly, Miller, Linda A., Zalacain, Magdalena, Holmes, David J., O'Dwyer, Karen
Gepubliceerd in Antimicrob Agents Chemother (2015)

Molecular Evolution Perspectives on Intraspecific Lateral DNA Transfer of Topoisomerase and Gyrase Loci in Streptococcus pneumoniae, with Implications for Fluoroquinolone Resistanc...

door Stanhope, Michael J., Walsh, Stacey L., Becker, Julie A., Italia, Michael J., Ingraham, Karen A., Gwynn, Michael N., Mathie, Tom, Poupard, James A., Miller, Linda A., Brown, James R., Amrine-Madsen, Heather
Gepubliceerd in 2005

Microbiological Analysis from a Phase 2 Randomized Study in Adults Evaluating Single Oral Doses of Gepotidacin in the Treatment of Uncomplicated Urogenital Gonorrhea Caused by Neis...

door Scangarella-Oman, Nicole E., Hossain, Mohammad, Dixon, Paula B., Ingraham, Karen, Min, Sharon, Tiffany, Courtney A., Perry, Caroline R., Raychaudhuri, Aparna, Dumont, Etienne F., Huang, Jianzhong, Hook, Edward W., Miller, Linda A.
Gepubliceerd in Antimicrob Agents Chemother (2018)

Selective Spectrum Antibiotic Modulation of the Gut Microbiome in Obesity and Diabetes Rodent Models

door Rajpal, Deepak K., Klein, Jean-Louis, Mayhew, David, Boucheron, Joyce, Spivak, Aaron T., Kumar, Vinod, Ingraham, Karen, Paulik, Mark, Chen, Lihong, Van Horn, Stephanie, Thomas, Elizabeth, Sathe, Ganesh, Livi, George P., Holmes, David J., Brown, James R.
Gepubliceerd in PLoS One (2015)

In Vitro Activity and Microbiological Efficacy of Gepotidacin from a Phase 2, Randomized, Multicenter, Dose-Ranging Study in Patients with Acute Bacterial Skin and Skin Structure I...

door Scangarella-Oman, Nicole E., Ingraham, Karen A., Tiffany, Courtney A., Tomsho, Lynn, Van Horn, Stephanie F., Mayhew, David N., Perry, Caroline R., Ashton, Theresa C., Dumont, Etienne F., Huang, Jianzhong, Brown, James R., Miller, Linda A.
Gepubliceerd in Antimicrob Agents Chemother (2020)

Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase

door Chan, Pan F., Germe, Thomas, Bax, Benjamin D., Huang, Jianzhong, Thalji, Reema K., Bacqué, Eric, Checchia, Anna, Chen, Dongzhao, Cui, Haifeng, Ding, Xiao, Ingraham, Karen, McCloskey, Lynn, Raha, Kaushik, Srikannathasan, Velupillai, Maxwell, Anthony, Stavenger, Robert A.
Gepubliceerd in Proc Natl Acad Sci U S A (2017)

Bacterial Resistance to Leucyl-tRNA Synthetase Inhibitor GSK2251052 Develops during Treatment of Complicated Urinary Tract Infections

door O'Dwyer, Karen, Spivak, Aaron T., Ingraham, Karen, Min, Sharon, Holmes, David J., Jakielaszek, Charles, Rittenhouse, Stephen, Kwan, Alan L., Livi, George P., Sathe, Ganesh, Thomas, Elizabeth, Van Horn, Stephanie, Miller, Linda A., Twynholm, Monique, Tomayko, John, Dalessandro, Marybeth, Caltabiano, Madelyn, Scangarella-Oman, Nicole E., Brown, James R.
Gepubliceerd in Antimicrob Agents Chemother (2014)

Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin

door Chan, Pan F., Srikannathasan, Velupillai, Huang, Jianzhong, Cui, Haifeng, Fosberry, Andrew P., Gu, Minghua, Hann, Michael M., Hibbs, Martin, Homes, Paul, Ingraham, Karen, Pizzollo, Jason, Shen, Carol, Shillings, Anthony J., Spitzfaden, Claus E., Tanner, Robert, Theobald, Andrew J., Stavenger, Robert A., Bax, Benjamin D., Gwynn, Michael N.
Gepubliceerd in Nat Commun (2015)

Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

door Machutta, Carl A., Kollmann, Christopher S., Lind, Kenneth E., Bai, Xiaopeng, Chan, Pan F., Huang, Jianzhong, Ballell, Lluis, Belyanskaya, Svetlana, Besra, Gurdyal S., Barros-Aguirre, David, Bates, Robert H., Centrella, Paolo A., Chang, Sandy S., Chai, Jing, Choudhry, Anthony E., Coffin, Aaron, Davie, Christopher P., Deng, Hongfeng, Deng, Jianghe, Ding, Yun, Dodson, Jason W., Fosbenner, David T., Gao, Enoch N., Graham, Taylor L., Graybill, Todd L., Ingraham, Karen, Johnson, Walter P., King, Bryan W., Kwiatkowski, Christopher R., Lelièvre, Joël, Li, Yue, Liu, Xiaorong, Lu, Quinn, Lehr, Ruth, Mendoza-Losana, Alfonso, Martin, John, McCloskey, Lynn, McCormick, Patti, O’Keefe, Heather P., O’Keeffe, Thomas, Pao, Christina, Phelps, Christopher B., Qi, Hongwei, Rafferty, Keith, Scavello, Genaro S., Steiginga, Matt S., Sundersingh, Flora S., Sweitzer, Sharon M., Szewczuk, Lawrence M., Taylor, Amy, Toh, May Fern, Wang, Juan, Wang, Minghui, Wilkins, Devan J., Xia, Bing, Yao, Gang, Zhang, Jean, Zhou, Jingye, Donahue, Christine P., Messer, Jeffrey A., Holmes, David, Arico-Muendel, Christopher C., Pope, Andrew J., Gross, Jeffrey W., Evindar, Ghotas
Gepubliceerd in Nat Commun (2017)

Author Correction: Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

door Machutta, Carl A., Kollmann, Christopher S., Lind, Kenneth E., Bai, Xiaopeng, Chan, Pan F., Huang, Jianzhong, Ballell, Lluis, Belyanskaya, Svetlana, Besra, Gurdyal S., Barros-Aguirre, David, Bates, Robert H., Centrella, Paolo A., Chang, Sandy S., Chai, Jing, Choudhry, Anthony E., Coffin, Aaron, Davie, Christopher P., Deng, Hongfeng, Deng, Jianghe, Ding, Yun, Dodson, Jason W., Fosbenner, David T., Gao, Enoch N., Graham, Taylor L., Graybill, Todd L., Ingraham, Karen, Johnson, Walter P., King, Bryan W., Kwiatkowski, Christopher R., Lelièvre, Joël, Li, Yue, Liu, Xiaorong, Lu, Quinn, Lehr, Ruth, Mendoza-Losana, Alfonso, Martin, John, McCloskey, Lynn, McCormick, Patti, O’Keefe, Heather P., O’Keeffe, Thomas, Pao, Christina, Phelps, Christopher B., Qi, Hongwei, Rafferty, Keith, Scavello, Genaro S., Steiginga, Matt S., Sundersingh, Flora S., Sweitzer, Sharon M., Szewczuk, Lawrence M., Taylor, Amy, Fern Toh, May, Wang, Juan, Wang, Minghui, Wilkins, Devan J., Xia, Bing, Yao, Gang, Zhang, Jean, Zhou, Jingye, Donahue, Christine P., Messer, Jeffrey A., Holmes, David, Arico-Muendel, Christopher C., Pope, Andrew J., Gross, Jeffrey W., Evindar, Ghotas
Gepubliceerd in Nat Commun (2018)