Variable Sensitivity to Bacterial Methionyl-tRNA Synthetase Inhibitors Reveals Subpopulations of Streptococcus pneumoniae with Two Distinct Methionyl-tRNA Synthetase Genes

As reported previously (J. R. Jarvest et al., J. Med. Chem. 45:1952-1962, 2002), potent inhibitors (at nanomolar concentrations) of Staphylococcus aureus methionyl-tRNA synthetase (MetS; encoded by metS1) have been derived from a high-throughput screening assay hit. Optimized compounds showed excell...

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Detalhes bibliográficos
Main Authors: Gentry, Daniel R., Ingraham, Karen A., Stanhope, Michael J., Rittenhouse, Stephen, Jarvest, Richard L., O'Hanlon, Peter J., Brown, James R., Holmes, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC155832/
https://ncbi.nlm.nih.gov/pubmed/12760849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.6.1784-1789.2003
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