Variable Sensitivity to Bacterial Methionyl-tRNA Synthetase Inhibitors Reveals Subpopulations of Streptococcus pneumoniae with Two Distinct Methionyl-tRNA Synthetase Genes

As reported previously (J. R. Jarvest et al., J. Med. Chem. 45:1952-1962, 2002), potent inhibitors (at nanomolar concentrations) of Staphylococcus aureus methionyl-tRNA synthetase (MetS; encoded by metS1) have been derived from a high-throughput screening assay hit. Optimized compounds showed excell...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Gentry, Daniel R., Ingraham, Karen A., Stanhope, Michael J., Rittenhouse, Stephen, Jarvest, Richard L., O'Hanlon, Peter J., Brown, James R., Holmes, David J.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2003
Schlagworte:	Mechanisms of Resistance
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC155832/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12760849/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.6.1784-1789.2003
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