Frequency of Spontaneous Resistance to Peptide Deformylase Inhibitor GSK1322322 in Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae

The continuous emergence of multidrug-resistant pathogenic bacteria is compromising the successful treatment of serious microbial infections. GSK1322322, a novel peptide deformylase (PDF) inhibitor, shows good in vitro antibacterial activity and has demonstrated safety and efficacy in human proof-of...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Min, Sharon, Ingraham, Karen, Huang, Jianzhong, McCloskey, Lynn, Rilling, Sarah, Windau, Anne, Pizzollo, Jason, Butler, Deborah, Aubart, Kelly, Miller, Linda A., Zalacain, Magdalena, Holmes, David J., O'Dwyer, Karen
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505285/
https://ncbi.nlm.nih.gov/pubmed/26014938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00484-15
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