Potent Sub-MIC Effect of GSK1322322 and Other Peptide Deformylase Inhibitors on In Vitro Growth of Staphylococcus aureus

Peptide deformylase (PDF), a clinically unexploited antibacterial target, plays an essential role in protein maturation. PDF inhibitors, therefore, represent a new antibiotic class with a unique mode of action that provides an alternative therapy for the treatment of infections caused by drug-resist...

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Bibliografiset tiedot
Päätekijät: Butler, Deborah, Chen, Dongzhao, O'Dwyer, Karen, Lewandowski, Thomas, Aubart, Kelly, Zalacain, Magdalena
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2014
Aiheet:
Mechanisms of Action: Physiological Effects
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910740/
https://ncbi.nlm.nih.gov/pubmed/24165188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01292-13
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