Pharmacokinetics/Pharmacodynamics of Peptide Deformylase Inhibitor GSK1322322 against Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus in Rodent Models of Infection

GSK1322322 is a novel inhibitor of peptide deformylase (PDF) with good in vitro activity against bacteria associated with community-acquired pneumonia and skin infections. We have characterized the in vivo pharmacodynamics (PD) of GSK1322322 in immunocompetent animal models of infection with Strepto...

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Hoover, Jennifer, Lewandowski, Thomas, Straub, Robert J., Novick, Steven J., DeMarsh, Peter, Aubart, Kelly, Rittenhouse, Stephen, Zalacain, Magdalena
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704172/
https://ncbi.nlm.nih.gov/pubmed/26482300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01842-15
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