mTORC1 restrains adipocyte lipolysis to prevent systemic hyperlipidemia

OBJECTIVE: Pharmacological agents targeting the mTOR complexes are used clinically as immunosuppressants and anticancer agents and can extend the lifespan of model organisms. An undesirable side effect of these drugs is hyperlipidemia. Although multiple roles have been described for mTOR complex 1 (...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Paolella, Lauren M., Mukherjee, Sarmistha, Tran, Cassie M., Bellaver, Bruna, Hugo, Mindy, Luongo, Timothy S., Shewale, Swapnil V., Lu, Wenyun, Chellappa, Karthikeyani, Baur, Joseph A.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6961719/
https://ncbi.nlm.nih.gov/pubmed/32029223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2019.12.003
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