mTORC1 restrains adipocyte lipolysis to prevent systemic hyperlipidemia

OBJECTIVE: Pharmacological agents targeting the mTOR complexes are used clinically as immunosuppressants and anticancer agents and can extend the lifespan of model organisms. An undesirable side effect of these drugs is hyperlipidemia. Although multiple roles have been described for mTOR complex 1 (...

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Dades bibliogràfiques
Publicat a:Mol Metab
Autors principals: Paolella, Lauren M., Mukherjee, Sarmistha, Tran, Cassie M., Bellaver, Bruna, Hugo, Mindy, Luongo, Timothy S., Shewale, Swapnil V., Lu, Wenyun, Chellappa, Karthikeyani, Baur, Joseph A.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2019
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6961719/
https://ncbi.nlm.nih.gov/pubmed/32029223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2019.12.003
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