Skeletal Muscle-specific G Protein-coupled Receptor Kinase 2 Ablation Alters Isolated Skeletal Muscle Mechanics and Enhances Clenbuterol-stimulated Hypertrophy

GRK2, a G protein-coupled receptor kinase, plays a critical role in cardiac physiology. Adrenergic receptors are the primary target for GRK2 activity in the heart; phosphorylation by GRK2 leads to desensitization of these receptors. As such, levels of GRK2 activity in the heart directly correlate wi...

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Vydáno v:J Biol Chem
Hlavní autoři: Woodall, Benjamin P., Woodall, Meryl C., Luongo, Timothy S., Grisanti, Laurel A., Tilley, Douglas G., Elrod, John W., Koch, Walter J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063976/
https://ncbi.nlm.nih.gov/pubmed/27566547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.721282
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