The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition

Cardiac contractility is mediated by variable flux in intracellular calcium (Ca(2+)), thought to be integrated into mitochondria via the mitochondrial calcium uniporter (MCU) channel to match energetic demand. Here we examine a conditional, cardiomyocyte-specific, mutant mouse lacking Mcu, the pore-...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Luongo, Timothy S., Lambert, Jonathan P., Yuan, Ancai, Zhang, Xueqian, Gross, Polina, Song, Jianliang, Shanmughapriya, Santhanam, Gao, Erhe, Jain, Mohit, Houser, Steven R., Koch, Walter J., Cheung, Joseph Y., Madesh, Muniswamy, Elrod, John W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517182/
https://ncbi.nlm.nih.gov/pubmed/26119731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.06.017
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