The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition

Cardiac contractility is mediated by variable flux in intracellular calcium (Ca(2+)), thought to be integrated into mitochondria via the mitochondrial calcium uniporter (MCU) channel to match energetic demand. Here we examine a conditional, cardiomyocyte-specific, mutant mouse lacking Mcu, the pore-...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cell Rep
Päätekijät: Luongo, Timothy S., Lambert, Jonathan P., Yuan, Ancai, Zhang, Xueqian, Gross, Polina, Song, Jianliang, Shanmughapriya, Santhanam, Gao, Erhe, Jain, Mohit, Houser, Steven R., Koch, Walter J., Cheung, Joseph Y., Madesh, Muniswamy, Elrod, John W.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2015
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517182/
https://ncbi.nlm.nih.gov/pubmed/26119731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.06.017
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