The mitochondrial Na(+)/Ca(2+) exchanger is essential for Ca(2+) homeostasis and viability

Mitochondrial calcium ((m)Ca(2+)) has a central role in both metabolic regulation and cell death signalling, however its role in homeostatic function and disease is controversial(1). Slc8b1 encodes the mitochondrial Na(+)/Ca(2+) exchanger (NCLX), which is proposed to be the primary mechanism for (m)...

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Publicado no:Nature
Main Authors: Luongo, Timothy S., Lambert, Jonathan P., Gross, Polina, Nwokedi, Mary, Lombardi, Alyssa A., Shanmughapriya, Santhanam, Carpenter, April C., Kolmetzky, Devin, Gao, Erhe, van Berlo, Jop H., Tsai, Emily J., Molkentin, Jeffery D., Chen, Xiongwen, Madesh, Muniswamy, Houser, Steven R., Elrod, John W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5731245/
https://ncbi.nlm.nih.gov/pubmed/28445457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22082
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