Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites

The conserved HIV-1 site of coreceptor binding is protected from antibody-directed neutralization by conformational and steric restrictions. While inaccessible to most human antibodies, the coreceptor site has been shown to be accessed by antibody fragments. In this study, we used X-ray crystallogra...

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Bibliografiset tiedot
Päätekijät: Acharya, Priyamvada, Luongo, Timothy S., Georgiev, Ivelin S., Matz, Julie, Schmidt, Stephen D., Louder, Mark K., Kessler, Pascal, Yang, Yongping, McKee, Krisha, O'Dell, Sijy, Chen, Lei, Baty, Daniel, Chames, Patrick, Martin, Loïc, Mascola, John R., Kwong, Peter D.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2013
Aiheet:
Vaccines and Antiviral Agents
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753989/
https://ncbi.nlm.nih.gov/pubmed/23843638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01332-13
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