Antibodies VRC01 and 10E8 neutralize HIV-1 with high breadth and potency even with immunoglobulin-framework regions substantially reverted to germline

Antibodies capable of effectively neutralizing HIV-1 generally exhibit very high levels of somatic hypermutation, both in their complementarity-determining and framework-variable regions. In many cases, full reversion of the antibody framework mutations back to germline has been shown to result in s...

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Hauptverfasser: Georgiev, Ivelin S., Rudicell, Rebecca S., Saunders, Kevin O., Shi, Wei, Kirys, Tatsiana, McKee, Krisha, O'Dell, Sijy, Chuang, Gwo-Yu, Yang, Zhi-Yong, Ofek, Gilad, Connors, Mark, Mascola, John R., Nabel, Gary J., Kwong, Peter D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140862/
https://ncbi.nlm.nih.gov/pubmed/24391217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302515
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