Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design

Extraordinary antibodies capable of near pan-neutralization of HIV-1 have been identified. One of the broadest is antibody 10E8, which recognizes the membrane-proximal external region (MPER) of the HIV-1 envelope and neutralizes >95% of circulating HIV-1 strains. If delivered passively, 10E8 migh...

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Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Kwon, Young D., Georgiev, Ivelin S., Ofek, Gilad, Zhang, Baoshan, Asokan, Mangaiarkarasi, Bailer, Robert T., Bao, Amy, Caruso, William, Chen, Xuejun, Choe, Misook, Druz, Aliaksandr, Ko, Sung-Youl, Louder, Mark K., McKee, Krisha, O'Dell, Sijy, Pegu, Amarendra, Rudicell, Rebecca S., Shi, Wei, Wang, Keyun, Yang, Yongping, Alger, Mandy, Bender, Michael F., Carlton, Kevin, Cooper, Jonathan W., Blinn, Julie, Eudailey, Joshua, Lloyd, Krissey, Parks, Robert, Alam, S. Munir, Haynes, Barton F., Padte, Neal N., Yu, Jian, Ho, David D., Huang, Jinghe, Connors, Mark, Schwartz, Richard M., Mascola, John R., Kwong, Peter D.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2016
Sujets:
Structure and Assembly
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907239/
https://ncbi.nlm.nih.gov/pubmed/27053554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03246-15
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