Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design

Extraordinary antibodies capable of near pan-neutralization of HIV-1 have been identified. One of the broadest is antibody 10E8, which recognizes the membrane-proximal external region (MPER) of the HIV-1 envelope and neutralizes >95% of circulating HIV-1 strains. If delivered passively, 10E8 migh...

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Veröffentlicht in:J Virol
Hauptverfasser: Kwon, Young D., Georgiev, Ivelin S., Ofek, Gilad, Zhang, Baoshan, Asokan, Mangaiarkarasi, Bailer, Robert T., Bao, Amy, Caruso, William, Chen, Xuejun, Choe, Misook, Druz, Aliaksandr, Ko, Sung-Youl, Louder, Mark K., McKee, Krisha, O'Dell, Sijy, Pegu, Amarendra, Rudicell, Rebecca S., Shi, Wei, Wang, Keyun, Yang, Yongping, Alger, Mandy, Bender, Michael F., Carlton, Kevin, Cooper, Jonathan W., Blinn, Julie, Eudailey, Joshua, Lloyd, Krissey, Parks, Robert, Alam, S. Munir, Haynes, Barton F., Padte, Neal N., Yu, Jian, Ho, David D., Huang, Jinghe, Connors, Mark, Schwartz, Richard M., Mascola, John R., Kwong, Peter D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Structure and Assembly
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907239/
https://ncbi.nlm.nih.gov/pubmed/27053554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03246-15
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