Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design

Extraordinary antibodies capable of near pan-neutralization of HIV-1 have been identified. One of the broadest is antibody 10E8, which recognizes the membrane-proximal external region (MPER) of the HIV-1 envelope and neutralizes >95% of circulating HIV-1 strains. If delivered passively, 10E8 migh...

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Bibliografske podrobnosti
izdano v:J Virol
Main Authors: Kwon, Young D., Georgiev, Ivelin S., Ofek, Gilad, Zhang, Baoshan, Asokan, Mangaiarkarasi, Bailer, Robert T., Bao, Amy, Caruso, William, Chen, Xuejun, Choe, Misook, Druz, Aliaksandr, Ko, Sung-Youl, Louder, Mark K., McKee, Krisha, O'Dell, Sijy, Pegu, Amarendra, Rudicell, Rebecca S., Shi, Wei, Wang, Keyun, Yang, Yongping, Alger, Mandy, Bender, Michael F., Carlton, Kevin, Cooper, Jonathan W., Blinn, Julie, Eudailey, Joshua, Lloyd, Krissey, Parks, Robert, Alam, S. Munir, Haynes, Barton F., Padte, Neal N., Yu, Jian, Ho, David D., Huang, Jinghe, Connors, Mark, Schwartz, Richard M., Mascola, John R., Kwong, Peter D.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2016
Teme:
Structure and Assembly
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907239/
https://ncbi.nlm.nih.gov/pubmed/27053554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03246-15
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