Structure-Based Design of a Small Molecule CD4-Antagonist with Broad Spectrum Anti-HIV-1 Activity

Earlier we reported the discovery and design of NBD-556 and their analogs which demonstrated their potential as HIV-1 entry inhibitors. However, progress in developing these inhibitors has been stymied by their CD4-agonist properties, an unfavorable trait for use as drug. Here, we demonstrate the su...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Curreli, Francesca, Kwon, Young Do, Zhang, Hongtao, Scacalossi, Daniel, Belov, Dmitry S., Tikhonov, Artur A., Andreev, Ivan A., Altieri, Andrea, Kurkin, Alexander V., Kwong, Peter D., Debnath, Asim K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4676410/
https://ncbi.nlm.nih.gov/pubmed/26301736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00709
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