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Design, synthesis and antiviral activity of entry inhibitors that target the CD4-binding site of HIV-1

The CD4 binding site on HIV-1 gp120 has been validated as a drug target to prevent HIV-1 entry to cells. Previously, we identified two small molecule inhibitors consisting of a 2,2,6,6-tetramethylpiperidine ring linked by an oxalamide to a p-halide-substituted phenyl group, which target this site, s...

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Detalhes bibliográficos
Main Authors: Curreli, Francesca, Choudhury, Spreeha, Pyatkin, Ilya, Zagorodnikov, Victor P., Bulay, Anna Khulianova, Altieri, Andrea, Kwon, Young Do, Kwong, Peter D., Debnath, Asim K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372086/
https://ncbi.nlm.nih.gov/pubmed/22524483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3002247
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