Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120

The site on HIV-1 gp120 that binds to the CD4 receptor is vulnerable to antibodies. However, most antibodies that interact with this site cannot neutralize HIV-1. To understand the basis of this resistance, we determined co-crystal structures for two poorly neutralizing, CD4–binding site (CD4BS) ant...

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Autors principals: Chen, Lei, Kwon, Young Do, Zhou, Tongqing, Wu, Xueling, O'Dell, Sijy, Cavacini, Lisa, Hessell, Ann J., Pancera, Marie, Tang, Min, Xu, Ling, Yang, Zhi-Yong, Zhang, Mei-Yun, Arthos, James, Burton, Dennis R., Dimitrov, Dimiter S., Nabel, Gary J., Posner, Marshall R., Sodroski, Joseph, Wyatt, Richard, Mascola, John R., Kwong, Peter D.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862588/
https://ncbi.nlm.nih.gov/pubmed/19965434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1175868
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