Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site

Efforts to develop therapeutic agents that inhibit HIV-1 entry have led to the identification of several small molecule leads. One of the most promising is the NBD series, which binds within a conserved gp120 cavity and possesses para-halogen substituted aromatic rings, a central oxalamide linker, a...

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Hauptverfasser: Kwon, Young Do, LaLonde, Judith M., Yang, Yongping, Elban, Mark A., Sugawara, Akihiro, Courter, Joel R., Jones, David M., Smith, Amos B., Debnath, Asim K., Kwong, Peter D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904841/
https://ncbi.nlm.nih.gov/pubmed/24489681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085940
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