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Fluctuation Dynamics Analysis of gp120 Envelope Protein Reveals a Topologically Based Communication Network

HIV infection is initiated by binding of the viral glycoprotein gp120, to the cellular receptor CD4. Upon CD4 binding, gp120 undergoes conformational change, permitting binding to the chemokine receptor. Crystal structures of gp120 ternary complex reveal the CD4 bound conformation of gp120. We repor...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Shrivastava, Indira, LaLonde, Judith M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494097/
https://ncbi.nlm.nih.gov/pubmed/20718047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22816
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