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Spontaneous Rearrangement of the β20/β21 Strands in Simulations of Unliganded HIV-1 Glycoprotein, gp120

Binding of the viral spike drives cell entry and infection by HIV-1 to the cellular CD4 and chemokine receptors with associated conformational change of the viral glycoprotein envelope, gp120. Crystal structures of the CD4-gp120-antibody ternary complex reveal a large internal gp120 cavity formed by...

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Bibliografske podrobnosti
Main Authors: Shrivastava, Indira, Wendel, Kaylee, LaLonde, Judith M.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464976/
https://ncbi.nlm.nih.gov/pubmed/22963284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300878d
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