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Spontaneous Rearrangement of the β20/β21 Strands in Simulations of Unliganded HIV-1 Glycoprotein, gp120
Binding of the viral spike drives cell entry and infection by HIV-1 to the cellular CD4 and chemokine receptors with associated conformational change of the viral glycoprotein envelope, gp120. Crystal structures of the CD4-gp120-antibody ternary complex reveal a large internal gp120 cavity formed by...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3464976/ https://ncbi.nlm.nih.gov/pubmed/22963284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300878d |
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