Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops

The HIV-1 envelope (Env) spike (gp120(3)/gp41(3)) undergoes considerable structural rearrangements to mediate virus entry into cells and to evade the host immune response. Engagement of CD4, the primary human receptor, fixes a particular conformation and primes Env for entry. The CD4-bound state, ho...

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Main Authors: Kwon, Young Do, Finzi, Andrés, Wu, Xueling, Dogo-Isonagie, Cajetan, Lee, Lawrence K., Moore, Lucas R., Schmidt, Stephen D., Stuckey, Jonathan, Yang, Yongping, Zhou, Tongqing, Zhu, Jiang, Vicic, David A., Debnath, Asim K., Shapiro, Lawrence, Bewley, Carole A., Mascola, John R., Sodroski, Joseph G., Kwong, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326499/
https://ncbi.nlm.nih.gov/pubmed/22451932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112391109
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