Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops

The HIV-1 envelope (Env) spike (gp120(3)/gp41(3)) undergoes considerable structural rearrangements to mediate virus entry into cells and to evade the host immune response. Engagement of CD4, the primary human receptor, fixes a particular conformation and primes Env for entry. The CD4-bound state, ho...

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Bibliografski detalji
Glavni autori: Kwon, Young Do, Finzi, Andrés, Wu, Xueling, Dogo-Isonagie, Cajetan, Lee, Lawrence K., Moore, Lucas R., Schmidt, Stephen D., Stuckey, Jonathan, Yang, Yongping, Zhou, Tongqing, Zhu, Jiang, Vicic, David A., Debnath, Asim K., Shapiro, Lawrence, Bewley, Carole A., Mascola, John R., Sodroski, Joseph G., Kwong, Peter D.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326499/
https://ncbi.nlm.nih.gov/pubmed/22451932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112391109
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