Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops

The HIV-1 envelope (Env) spike (gp120(3)/gp41(3)) undergoes considerable structural rearrangements to mediate virus entry into cells and to evade the host immune response. Engagement of CD4, the primary human receptor, fixes a particular conformation and primes Env for entry. The CD4-bound state, ho...

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Bibliografiske detaljer
Main Authors: Kwon, Young Do, Finzi, Andrés, Wu, Xueling, Dogo-Isonagie, Cajetan, Lee, Lawrence K., Moore, Lucas R., Schmidt, Stephen D., Stuckey, Jonathan, Yang, Yongping, Zhou, Tongqing, Zhu, Jiang, Vicic, David A., Debnath, Asim K., Shapiro, Lawrence, Bewley, Carole A., Mascola, John R., Sodroski, Joseph G., Kwong, Peter D.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326499/
https://ncbi.nlm.nih.gov/pubmed/22451932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112391109
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