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Binding Thermodynamics of a Small-Molecular-Weight CD4 Mimetic to HIV-1 gp120
NBD-556 and the chemically and structurally similar NBD-557 are two low-molecular-weight compounds that reportedly block the interaction between the HIV-1 envelope glycoprotein gp120 and its receptor, CD4. NBD-556 binds to gp120 with a binding affinity of 2.7 × 10(5) M(−1) (K(d) = 3.7 μM) in a proce...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2504686/ https://ncbi.nlm.nih.gov/pubmed/16953583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi061193r |
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