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Optimization of CD4/gp120 Inhibitors by Thermodynamic Guided Alanine Scanning Mutagenesis

Since protein/protein interactions usually trigger signaling processes, inhibitors of those interactions must preclude protein binding without eliciting the signaling process themselves. To accomplish those goals, small molecules need to target those protein residues that contribute the most to bind...

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Detalhes bibliográficos
Main Authors: Liu, Yingyun, Schön, Arne, Freire, Ernesto
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527665/
https://ncbi.nlm.nih.gov/pubmed/23066870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.12075
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