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Optimization of CD4/gp120 Inhibitors by Thermodynamic Guided Alanine Scanning Mutagenesis
Since protein/protein interactions usually trigger signaling processes, inhibitors of those interactions must preclude protein binding without eliciting the signaling process themselves. To accomplish those goals, small molecules need to target those protein residues that contribute the most to bind...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3527665/ https://ncbi.nlm.nih.gov/pubmed/23066870 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.12075 |
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